Same here with R7 5700x and a 3060ti . I did all the game wuthout any problems. Just wanted to try the 2.0 and Freeze/crash on the main menu, sometimes character creation, sometimes on "CD Projekt start screen"........

Reddit helped: "In the settings -> GamePlay, under miscellaneous, you will be able to find option to enable/disable cross-platform saves. ... set it to disabled" resolved crash issue when return to main-menu.

Really similar specs like the OP "CaptBricks"
Core i9 13900k
RTX 4090
64Go Corsaire DDR5 6400mhz
1TB NVME

Game crashes at least every 5 min... it's unplayable even with the graphics setting to the lowest setting.

Sometimes i have a dialog box telling me the game crashed but i can continu to play like nothing happened... it's really strange.

It's the only game doing this.

Version=1
EventType=REDEngineErrorReport
EventTime=0
ReportIdentifier=ffffffff-ffffffff-00000001-00000000
Sig[0].Name=StackHash
Sig[0].Value=0x0000000000000000
Sig[1].Name=ErrorReason
Sig[1].Value=Unhandled exception
Sig[2].Name=InternalVersion
Sig[2].Value=3.0.4902785 P4CL: 6408866 Stream: //R6.Root/R6.Release
DynamicSig[1].Name=OS Version
DynamicSig[1].Value=10.0.22621.2.0.0.256.1
LoadedModule[0]=Cyberpunk2077.exe
LoadedModule[1]=ntdll.dll
LoadedModule[2]=KERNEL32.DLL
LoadedModule[3]=KERNELBASE.dll
LoadedModule[4]=apphelp.dll
LoadedModule[5]=USER32.dll
LoadedModule[6]=win32u.dll
LoadedModule[7]=GDI32.dll
LoadedModule[8]=gdi32full.dll
LoadedModule[9]=msvcp_win.dll
LoadedModule[10]=ucrtbase.dll
LoadedModule[11]=ADVAPI32.dll
LoadedModule[12]=msvcrt.dll
LoadedModule[13]=sechost.dll
LoadedModule[14]=RPCRT4.dll
LoadedModule[15]=SHELL32.dll
LoadedModule[16]=ole32.dll
LoadedModule[17]=sl.interposer.dll
LoadedModule[18]=dbghelp.dll
LoadedModule[19]=combase.dll
LoadedModule[20]=SETUPAPI.dll
LoadedModule[21]=WS2_32.dll
LoadedModule[22]=OLEAUT32.dll
LoadedModule[23]=libxess.dll
LoadedModule[24]=SHLWAPI.dll
LoadedModule[25]=PhysX3CharacterKinematic_x64.dll
LoadedModule[26]=PhysX3Cooking_x64.dll
LoadedModule[27]=PxFoundation_x64.dll
LoadedModule[28]=PhysX3_x64.dll
LoadedModule[29]=PhysX3Common_x64.dll
LoadedModule[30]=bink2w64.dll
LoadedModule[31]=HID.DLL
LoadedModule[32]=WINMM.dll
LoadedModule[33]=redlexer_native.dll
LoadedModule[34]=libcurl.dll
LoadedModule[35]=WLDAP32.dll
LoadedModule[36]=CRYPT32.dll
LoadedModule[37]=Normaliz.dll
LoadedModule[38]=XINPUT9_1_0.dll
LoadedModule[39]=VERSION.dll
LoadedModule[40]=POWRPROF.dll
LoadedModule[41]=icuuc.dll
LoadedModule[42]=icuin.dll
LoadedModule[43]=MSVCP140.dll
LoadedModule[44]=VCRUNTIME140.dll
LoadedModule[45]=d3d12.dll
LoadedModule[46]=dxgi.dll
LoadedModule[47]=CFGMGR32.dll
LoadedModule[48]=XeFX.dll
LoadedModule[49]=XeFX_Loader.dll
LoadedModule[50]=VCRUNTIME140_1.dll
LoadedModule[51]=amd_ags_x64.dll
LoadedModule[52]=dbgcore.DLL
LoadedModule[53]=oo2ext_7_win64.dll
LoadedModule[54]=REDGalaxy64.dll
LoadedModule[55]=WININET.dll
LoadedModule[56]=bcrypt.dll
LoadedModule[57]=IPHLPAPI.DLL
LoadedModule[58]=MSWSOCK.dll
LoadedModule[59]=icudt.dll
LoadedModule[60]=IMM32.DLL
LoadedModule[61]=UMPDC.dll
LoadedModule[62]=CRYPTBASE.DLL
LoadedModule[63]=bcryptPrimitives.dll
LoadedModule[64]=kernel.appcore.dll
LoadedModule[65]=windows.storage.dll
LoadedModule[66]=wintypes.dll
LoadedModule[67]=SHCORE.dll
LoadedModule[68]=napinsp.dll
LoadedModule[69]=pnrpnsp.dll
LoadedModule[70]=DNSAPI.dll
LoadedModule[71]=NSI.dll
LoadedModule[72]=winrnr.dll
LoadedModule[73]=wshbth.dll
LoadedModule[74]=nlansp_c.dll
LoadedModule[75]=fwpuclnt.dll
LoadedModule[76]=rasadhlp.dll
LoadedModule[77]=secur32.dll
LoadedModule[78]=SSPICLI.DLL
LoadedModule[79]=clbcatq.dll
LoadedModule[80]=wbemprox.dll
LoadedModule[81]=wbemcomn.dll
LoadedModule[82]=wbemsvc.dll
LoadedModule[83]=fastprox.dll
LoadedModule[84]=amsi.dll
LoadedModule[85]=USERENV.dll
LoadedModule[86]=profapi.dll
LoadedModule[87]=MpOav.dll
LoadedModule[88]=GameServicesGOG.dll
LoadedModule[89]=Galaxy64.dll
LoadedModule[90]=dxcore.dll
LoadedModule[91]=directxdatabasehelper.dll
LoadedModule[92]=uxtheme.dll
LoadedModule[93]=iertutil.dll
LoadedModule[94]=ondemandconnroutehelper.dll
LoadedModule[95]=WINNSI.DLL
LoadedModule[96]=WINHTTP.dll
LoadedModule[97]=schannel.DLL
LoadedModule[98]=ncrypt.dll
LoadedModule[99]=NTASN1.dll
LoadedModule[100]=ncryptsslp.dll
LoadedModule[101]=CChromaEditorLibrary64.dll
LoadedModule[102]=WINTRUST.dll
LoadedModule[103]=mfc140u.dll
LoadedModule[104]=Comctl32.dll
LoadedModule[105]=MSASN1.dll
LoadedModule[106]=CRYPTSP.dll
LoadedModule[107]=rsaenh.dll
LoadedModule[108]=imagehlp.dll
LoadedModule[109]=gpapi.dll
LoadedModule[110]=cryptnet.dll
LoadedModule[111]=sl.common.dll
LoadedModule[112]=drvstore.dll
LoadedModule[113]=devobj.dll
LoadedModule[114]=wldp.dll
LoadedModule[115]=nvapi64.dll
LoadedModule[116]=sl.dlss.dll
LoadedModule[117]=_nvngx.dll
LoadedModule[118]=DEVRTL.dll
LoadedModule[119]=SPINF.dll
LoadedModule[120]=ntmarta.dll
LoadedModule[121]=nvngx_dlss.dll
LoadedModule[122]=nvngx_dlssg.dll
LoadedModule[123]=vulkan-1.dll
LoadedModule[124]=nvcuda.dll
LoadedModule[125]=nvngx_dlssd.dll
LoadedModule[126]=sl.dlss_d.dll
LoadedModule[127]=sl.dlss_g.dll
LoadedModule[128]=sl.reflex.dll
LoadedModule[129]=GFSDK_Aftermath_Lib.x64.dll
LoadedModule[130]=nvwgf2umx.dll
LoadedModule[131]=D3D12Core.dll
LoadedModule[132]=nvspcap64.dll
LoadedModule[133]=DINPUT8.dll
LoadedModule[134]=inputhost.dll
LoadedModule[135]=CoreMessaging.dll
LoadedModule[136]=dhcpcsvc.DLL
LoadedModule[137]=nvldumdx.dll
LoadedModule[138]=NvCamera64.dll
LoadedModule[139]=d3d11.dll
LoadedModule[140]=WindowsCodecs.dll
LoadedModule[141]=MessageBus.dll
LoadedModule[142]=d3dcompiler_47_64.dll
LoadedModule[143]=D3DSCache.dll
LoadedModule[144]=twinapi.appcore.dll
LoadedModule[145]=nvcuda64.dll
LoadedModule[146]=nvrtum64.dll
LoadedModule[147]=NvTelemetryAPI64.dll
LoadedModule[148]=NvTelemetryBridge64.dll
LoadedModule[149]=MMDevApi.dll
LoadedModule[150]=AUDIOSES.DLL
LoadedModule[151]=Windows.UI.dll
LoadedModule[152]=resourcepolicyclient.dll
LoadedModule[153]=Wtsapi32.dll
LoadedModule[154]=XInput1_4.dll
LoadedModule[155]=deviceaccess.dll
LoadedModule[156]=MSCTF.dll
LoadedModule[157]=textinputframework.dll
LoadedModule[158]=dcomp.dll
LoadedModule[159]=dwmapi.dll
LoadedModule[160]=WINSTA.dll
LoadedModule[161]=MessageBus.dll
LoadedModule[162]=CoreUIComponents.dll
LoadedModule[163]=nvofapi64.dll
AppName=Cyberpunk2077.exe

This is very interesting to me, as this solution fixed a crashing problem in BG3 at its release. If this is what's causing the crash for a decent amount of people (I'm not experiencing a crash, so I can't say for sure) then the fix being this simple is a big plus.