The CEP is rather popular, as in many PW's and single player mods use it to some extent, so it's generally a good download. Other than that, haks are module dependent, so they only apply to mods that they've been added to/used in.
There are some nice overrides (GUI, hands, texture overrides, colored icons, etc) but they're obviously optional. Some of them are worth a look.
Ultimately, it depends on what you decide to do. There's not really a "catch all" when it comes to custom material. I've played on servers that just use the CEP. I've played on some that use gigs of other custom haks. The one I currently play on uses zero haks.
I wish I could be more help, but it's really a matter of where/what you decide to play.