MrBMT: I've come across quite a few unreachable chests/boxes/bags/book shelves (not the big ones touching the floor, but the standalone ones part of the way up a wall) in the 100 or so hours I've played so far. (And no, they've not accessible via different angles, jumping on other things, destroying stuff with aard, etc.)
The easy fix I imagine would be for to increase the loot radius (as in, so you can loot things from further away), so here's hoping CDPR do that.
I too have encountered a half dozen to a dozen things I could not get, sometimes it is multiple barrels stacked in a corner somewhere and you can get all but the one in the back, other times a top shelf thing in someone's house, etc. Ultimately anything that is intended to be attainable should be easy to get to without having to waltz around the map as that just removes one from immersion. This is one thing that I liked about Skyrim, was being able to go into First Person mode, point the cursor at something and you can take it if it is takeable.